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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1

Shiqiong Yang1, Christophe Pannecouque, Dirk Daelemans

  • 1Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, People's Republic of China.

European Journal of Medicinal Chemistry
|May 28, 2013
PubMed

Keywords:
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide50% cell culture infectious dose50% cytotoxic concentration50% effective concentration50% inhibitory concentrationAZTAntiviral activityBPsBenzophenoneCC(50)CCID(50)DAPYsDLVDiarylpyrimidineEC(50)EFVESIHIV-1HIV-1 RTHuman immunodeficiency virus type 1 reverse transcriptaseIC(50)K(d)MTTMolecular hybridizationNNIBPNNRTIsNVPODSITMC125TMC278TMSUSFDAUnited States Food and Drug Administrationbenzophenone derivativesdelavirdinediarylpyrimidine derivativesdissociation constantefavirenzelectrospray ionizationetravirinenevirapinenon-nucleoside RT inhibitorsnon-nucleoside inhibitor binding pocketnon-nucleoside reverse transcriptase inhibitorsoptical densityrilpivirineselectivity indextetramethylsilanewild-typewtzidovudine

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