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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Prognostic value of diastolic dysfunction: state of the art review

Wael A AlJaroudi1, James D Thomas, L Leonardo Rodriguez

  • 1From the *Division of Cardiovascular Medicine, American University of Beirut Medical Center, Beirut, Lebanon; and †Heart and Vascular Imaging Institute, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio.

Cardiology in Review
|May 28, 2013
PubMed

Insights

Left ventricular diastolic dysfunction (DD) significantly impacts heart failure outcomes. Echocardiography is key for assessing this dynamic condition, with its improvement linked to better survival.

Area of Science:

  • Cardiology
  • Echocardiography
  • Heart Failure Research

Background:

  • Left ventricular diastolic dysfunction (DD) is a major factor in diastolic heart failure, increasing patient morbidity and mortality.
  • Echocardiographic evaluation of diastolic function is a standard part of cardiac assessments, per major society guidelines.
  • Diastolic function is dynamic, with changes correlating to patient outcomes; improvement suggests better survival.

Purpose of the Study:

  • To review echocardiographic methods for assessing left ventricular diastolic function.
  • To explore the clinical implications and prognostic value of diastolic dysfunction.
  • To provide an integrative, practical approach to diastolic function assessment and discuss future research.

Main Methods:

  • Review of current echocardiographic guidelines and techniques for diastolic function assessment.
  • Analysis of studies linking diastolic dysfunction to clinical outcomes.
  • Synthesis of data on the prognostic significance of left and right ventricular DD.

Main Results:

  • Diastolic dysfunction is a significant predictor of adverse outcomes in heart failure.
  • Improved diastolic function correlates with enhanced patient survival.
  • Echocardiography provides crucial prognostic information regarding diastolic function.

Conclusions:

  • Echocardiography is essential for evaluating diastolic dysfunction and guiding patient management.
  • Understanding the dynamic nature of diastolic function improves prognostic accuracy.
  • Further research is needed to fully elucidate the mechanisms and therapeutic targets for diastolic dysfunction.

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