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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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Related Experiment Video

Updated: May 11, 2026

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
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Published on: December 20, 2024

Radiolabeled amino acids for oncologic imaging.

Chaofeng Huang1, Jonathan McConathy

  • 1Department of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|May 28, 2013
PubMed
Summary

Radiolabeled amino acids (AAs) are crucial for molecular imaging of tumors by targeting increased AA transport. New tracers targeting various transporters show promise for brain tumors, neuroendocrine tumors, and prostate cancer.

Keywords:
PETSPECTamino acidstumor imaging

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Molecular Imaging

Background:

  • Radiolabeled amino acids (AAs) are vital imaging agents for PET and SPECT.
  • Tumor cells exhibit increased amino acid (AA) transport, making them targets for imaging agents.

Purpose of the Study:

  • To review radiolabeled amino acids as molecular imaging agents for oncologic imaging.
  • To highlight current applications and tracer considerations for radiolabeled amino acids in cancer diagnosis.

Main Methods:

  • Review of existing literature on radiolabeled amino acid tracers.
  • Focus on System L amino acid transporter tracers and newer tracers targeting other transporters.
  • Analysis of clinical applications in brain tumors, neuroendocrine tumors, and prostate cancer.

Main Results:

  • System L amino acid transporter tracers are effective for brain tumor imaging.
  • Emerging data suggest utility in neuroendocrine tumors and prostate cancer.
  • Newer (18)F-labeled amino acids target diverse transporters (System A, glutamine, xCT, cationic AA transporters).

Conclusions:

  • Radiolabeled amino acids represent a significant class of molecular imaging agents.
  • Ongoing development of novel tracers broadens their oncologic imaging potential.
  • These agents are increasingly important for diagnosing and monitoring various cancers.