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Related Concept Videos

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...

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Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy
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B(1) mapping with a pure phase encode approach: quantitative density profiling.

S Vashaee1, B Newling, B MacMillan

  • 1UNB MRI Centre, Department of Physics, University of New Brunswick, Fredericton, New Brunswick, Canada E3B 5A3.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|May 28, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces a new MRI method to map B1 field inhomogeneities. The technique corrects image intensity variations, improving quantitative MRI accuracy and reliability.

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Medical Physics
  • Biophysics

Background:

  • Non-uniform image intensities in MRI often stem from B1 field inhomogeneities.
  • These variations limit quantitative MRI accuracy.
  • The principle of reciprocity relates received signal to the applied B1 field magnitude.

Purpose of the Study:

  • To develop a novel method for mapping B1 field inhomogeneities in MRI.
  • To enable correction of non-uniformities in MR images.
  • To improve the quantitative capabilities of MRI.

Main Methods:

  • Utilizes centric-scan pure phase encode MRI measurements.
  • Acquires successive images with systematically incremented low flip angle excitation pulses.
  • Exploits the B1(2) proportionality of local image intensity variation for high sensitivity.

Main Results:

  • A novel method for mapping B1 inhomogeneities is described.
  • The resultant B1 maps can correct MR image non-uniformities.
  • The method is robust in challenging regions, including near metallic structures.

Conclusions:

  • The presented technique provides simple, reliable, and robust B1 field mapping.
  • Quantitative density images can be achieved by correcting measurements with B1 field maps.
  • This method enhances the precision and reliability of MRI for quantitative analysis.