Study on antitubercular constituents from the seeds of Nigella glandulifera
Lian-li Sun1, Ming Luan, Wei Zhu
1The Key Laboratory of Biomedical Engineering, Ministry of Education, China, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China.
Chemical & Pharmaceutical Bulletin
|May 28, 2013
Abstract:
Two new compounds with five known compounds have been isolated from EtOH extract of the seeds of Nigella glandulifera. On the basis of their spectroscopic and chemical evidence, the new compounds were elucidated as methoxynigeglanine (1) and 6-methoxythymol-3-O-β-D-glucopyranoside (4). Compounds 1-4 showed moderate antitubercular activity against Mycobacterium tuberculosis strain H37Rv with minimal inhibitory concentration (MIC) values of 32-250 µg/mL.