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Experimental chronic wasting disease in wild type VM mice
Yoon-Hee Lee1, Hyun-Joo Sohn, Min-Jeong Kim
1OIE Reference Laboratory for CWD, Animal, Plant and Fisheries Quarantine and Inspection Agency, Ministry for Food, Agriculture, Forestry and Fisheries, Anyang 430-757, Republic of Korea.
The Journal of Veterinary Medical Science
|May 28, 2013
Summary
Chronic Wasting Disease (CWD) research shows successful experimental transmission to conventional VM/Dk mice. This breakthrough offers a valuable new model for studying CWD in wild type mice.
Area of Science:
- Veterinary Science
- Neuroscience
- Prion Disease Research
Background:
- Chronic Wasting Disease (CWD) is a transmissible spongiform encephalopathy affecting cervids in North America.
- CWD was first identified in the Republic of Korea in 2001, with subsequent cases confirmed.
- Previous studies showed CWD transmission to transgenic mice but not wild type mice.
Purpose of the Study:
- To investigate the experimental transmission of elk CWD to conventional VM/Dk mice.
- To establish a reliable animal model for CWD research.
Main Methods:
- Experimental inoculation of elk CWD prions into VM/Dk mice.
- Assessment of disease progression and attack rate through serial passages.
Main Results:
- Successful transmission of elk CWD to conventional VM/Dk mice was achieved.
- A 100% attack rate was observed after the second passage.
- CWD prions were detected in affected wild type mice.
Conclusions:
- Conventional VM/Dk mice can be experimentally infected with elk CWD.
- These CWD-affected mice provide a valuable new model for future research.
- This model will aid in understanding CWD pathogenesis and developing countermeasures.
