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Clinical use of novel biomarkers in heart failure: towards personalized medicine

Daniela Schmitter1, Gadi Cotter, Adriaan A Voors

  • 1Momentum Research, Inc., Hagmattstrasse 17, 4123, Allschwil, Switzerland.

Heart Failure Reviews
|May 28, 2013
PubMed

Insights

Novel heart failure biomarkers offer more than just prognosis. This review explores their roles in diagnosis, personalized therapy selection, and potential as therapeutic targets, comparing them to established natriuretic peptides.

Area of Science:

  • Cardiology and Clinical Biochemistry
  • Biomarker Discovery and Validation

Background:

  • Heart failure biomarkers are crucial for understanding disease mechanisms and identifying high-risk patients.
  • Current research predominantly focuses on the prognostic value of biomarkers, with clinical applicability needing further establishment.
  • Biomarkers have broader potential applications beyond prognostication in heart failure management.

Purpose of the Study:

  • To review the established and potential clinical value of novel heart failure biomarkers.
  • To compare the utility of novel biomarkers with established natriuretic peptides.
  • To discuss the application of biomarkers in diagnosis, personalized therapy selection, and as therapeutic targets.

Main Methods:

  • Literature review of established and emerging heart failure biomarkers.
  • Analysis of biomarker roles in diagnosis, risk stratification, therapy selection, and as therapeutic targets.
  • Comparative assessment of novel biomarkers against reference markers like natriuretic peptides.

Main Results:

  • Novel biomarkers including mid-regional atrial natriuretic peptide, soluble ST2, growth differentiation factor 15, galectin-3, renal tubular damage markers, and microRNAs show promise.
  • These biomarkers offer potential applications in diagnosing heart failure and guiding personalized treatment strategies.
  • Certain biomarkers may even serve as direct targets for future heart failure therapies.

Conclusions:

  • Novel heart failure biomarkers possess significant potential beyond prognostication.
  • Their roles in diagnosis, personalized therapy, and as therapeutic targets warrant further investigation and clinical validation.
  • These biomarkers represent a valuable addition to the management of heart failure, complementing existing markers.

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