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Updated: May 11, 2026
07:18
Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
Published on: February 18, 2022
Diagnosing vascular variability anomalies, not only MESOR-hypertension
Franz Halberg1, Deborah Powell, Kuniaki Otsuka
1University of Minnesota Academic Health Center, Minneapolis, MN 55455, USA.
Summary
Chronobiology and chronomics reveal how environmental cycles affect biological rhythms. Analyzing blood pressure data identifies vascular variability anomalies linked to disease risk, even within normal ranges.
Area of Science:
- Chronobiology and chronomics
- Physiological-physical interactions
- Biosphere-environment cycles
Background:
- Biological rhythms are studied in chronobiology.
- Chronomics explores environmental cycle interactions with genetic coding.
- Human blood pressure exhibits measurable responses to geomagnetic forces.
Purpose of the Study:
- To interpret ambulatory blood pressure monitoring (C-ABPM) data using chronobiological and chronomic principles.
- To identify vascular variability anomalies (VVAs) for disease risk assessment.
- To explore the link between VVAs and cardiovascular, cerebrovascular, and renovascular disease risk.
Main Methods:
- Application of analytical global and local methods to long-term human blood pressure records.
- Utilizing time-specified reference values from healthy peers (matched by sex and age) for VVA identification.
- Leveraging C-ABPM data for assessing physiological-physical interactions and disease risk.
Main Results:
- VVAs detected even within conventionally normal blood pressure ranges indicate increased disease risk.
- Long-term C-ABPM aids in self-understanding and lifestyle adjustment for strain reduction.
- Persistent circadian VVAs can be treated, often by adjusting medication timing.
Conclusions:
- Circadian VVA assessment is a critical global health priority due to high blood pressure-related mortality.
- C-ABPM can serve as a valuable tool complementing environmental monitoring for understanding health cataclysms.
- Integrating C-ABPM into public health initiatives can improve noncommunicable disease management.
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