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Against all odds: anti-IgE for intrinsic asthma?
Marek Lommatzsch1, Stephanie Korn, Roland Buhl
1Department of Pneumology and Critical Care Medicine, University of Rostock, , Rostock, Germany.
Abstract:
For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be effective in patients with intrinsic asthma. Therefore, large and well-controlled clinical trials with anti-IgE are urgently warranted in patients with intrinsic asthma. In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment.
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