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Localized pseudomembranous colitis in the cecum and ascending colon mimicking acute appendicitis

Ju Won Chyung1, Dong Gue Shin

  • 1Ju Won Chyung, Dong Gue Shin, Department of Surgery, Seoul Medical Center, Seoul 889-5, South Korea.

World Journal of Gastrointestinal Surgery
|May 28, 2013
PubMed

Insights

A 61-year-old male experienced abdominal pain and diarrhea after taking cefixime. He was diagnosed with localized pseudomembranous colitis, which resolved with metronidazole treatment.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antibiotic-associated diarrhea is a common complication.
  • Pseudomembranous colitis can be localized or diffuse.
  • Third-generation cephalosporins are associated with Clostridioides difficile infection.

Purpose of the Study:

  • To report a case of localized pseudomembranous colitis.
  • To highlight the association between cefixime and this condition.
  • To emphasize the importance of considering drug-induced colitis in differential diagnosis.

Main Methods:

  • Case report of a 61-year-old male.
  • Clinical presentation: abdominal pain, watery diarrhea.
  • Diagnostic tools: colonoscopy, medical history review.
  • Treatment: oral metronidazole.

Main Results:

  • Colonoscopy revealed pseudomembranes in the cecum and ascending colon.
  • Symptoms resolved completely after 7 days of metronidazole.
  • The patient had a history of cefixime use for otitis media.

Conclusions:

  • Cefixime can cause localized pseudomembranous colitis.
  • This condition can mimic acute appendicitis.
  • Prompt diagnosis and treatment with metronidazole are effective.
Keywords:
AbdomenAcuteAppendicitisCefiximeDiarrheaEnterocolitisPseudomembranous

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