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Heart and Brain: A neutro-genomic link

Vivek Priy Dave1, Deepak Kaul

  • 1Central Lab, R and D Center, Gangwon-do 200-883, South Korea.

World Journal of Biological Chemistry
|May 28, 2013
PubMed

Insights

Nutritional genomics explores how diet and genes interact to influence health, particularly the heart-brain connection. Understanding these interactions, like dietary regulation of Liver X Receptor-alpha, can help prevent chronic diseases.

Area of Science:

  • Cardiovascular and Neurological Sciences
  • Nutritional Genomics
  • Molecular Biology

Background:

  • The historical separation of heart and brain health is challenged by modern medicine's focus on the heart-brain connection for complex disorders.
  • The concept of diet-genome interactions influencing disease is ancient, but nutritional genomics offers new insights.
  • Dietary chemicals regulate gene expression, implicating diet-regulated genes in disease development and severity.

Purpose of the Study:

  • To explore nutritional genomics as a holistic approach to understanding diet-health relationships.
  • To investigate the role of dietary components in regulating key factors like Liver X Receptor-alpha.
  • To identify disease-preventing and health-promoting foods aligned with lifestyle, culture, and genetics.

Main Methods:

  • Investigated the role of nutritional genomics in diet-health-gene interactions.
  • Focused on the regulation of Liver X Receptor-alpha (a key transcription factor) by dietary components.
  • Utilized findings from molecular biology research at PGIMER, Chandigarh.

Main Results:

  • Liver X Receptor-alpha, implicated in coronary heart disease and neurodegenerative diseases, is regulated by dietary components.
  • Dietary chemicals directly and indirectly influence gene expression, impacting disease.
  • Research highlights the potential of nutritional genomics to understand complex disease pathways.

Conclusions:

  • Nutritional genomics provides a systems approach to understanding the intricate relationship between diet, genes, and health.
  • Targeting the heart-brain connection through diet holds promise for managing cardiovascular and neurological disorders.
  • Personalized nutrition, considering lifestyle, culture, and genetics, is key for disease prevention and health promotion.

Keywords:
BrainGene interactionHeartLiver X ReceptorNutrition

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