Meibomian gland dysfunction: some clinical, biochemical and physical observations

Dysfunction of the meibomian glands resulting from contact lens wear has recently been recognized. This study shows that 30% of lens wearers develop some degree of meibomian gland dysfunction after 6 months of wear whereas only 20% of non-lens wearers have similar problem. Thirty-three per cent of the male wearers have dysfunctioning glands compared with 28% of female wearers. The incidence does not depend on the type of lenses worn. There was no detectable differences between the composition of the abnormal fluid secreted by the dysfunctioning glands and the clear fluid coming out of the normal unblocked glands, as shown by thin layer chromatography. On studying the melting point of the lipids, we found that material from abnormal glands melted at approximately 3 degrees C higher than the normal fluid.