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Updated: May 11, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
[Selective progesterone receptor modulators and their therapeutical use]
D Driák1, B Sehnal, I Svandová
1Gynekologicko-porodnická Klinika 1. LF UK a Nemocnice Na Bulovce, Praha, Prednosta prof MUDr. M. Halaska, DrSc. driak@seznam.cz
Abstract:
Currently developed selective progesterone receptor modulators (SPRMs) are steroid derived compounds with a bulky radical substitution at carbon 11. They interact with progesterone receptor and exert antagonistic or/and agonistic effects. Mifepristone was approved for pregnancy termination and ulipristal acetate as emergency contraception and pharmacological therapy of uterine fibroids. SPRMs inhibit endometrial proliferation and myoma growth, this suggests a therapeutical effect in cases of endometriosis and other estrogen-dependent diseases.
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