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Related Experiment Video

Updated: May 11, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

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[Selective progesterone receptor modulators and their therapeutical use].

D Driák¹, B Sehnal, I Svandová

¹Gynekologicko-porodnická Klinika 1. LF UK a Nemocnice Na Bulovce, Praha, Prednosta prof MUDr. M. Halaska, DrSc. driak@seznam.cz

Ceska Gynekologie

|May 29, 2013

Summary

Selective progesterone receptor modulators (SPRMs) are steroid-derived drugs that target the progesterone receptor. Their ability to inhibit endometrial and myoma growth suggests potential therapeutic applications for endometriosis and other estrogen-dependent diseases.

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Reproductive Techniques for Ovarian Monitoring and Control in Amphibians

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Reproductive Techniques for Ovarian Monitoring and Control in Amphibians

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Published on: May 12, 2019

Area of Science:

Pharmacology
Endocrinology
Reproductive Medicine

Background:

Selective progesterone receptor modulators (SPRMs) are a class of steroid-derived compounds.
These modulators interact with the progesterone receptor, exhibiting antagonistic or agonistic effects.

Purpose of the Study:

To explore the therapeutic potential of SPRMs in estrogen-dependent diseases.
To highlight the mechanism of action of SPRMs in inhibiting endometrial proliferation and myoma growth.

Main Methods:

Review of current literature on SPRM development and applications.
Analysis of the pharmacological effects of SPRMs on the progesterone receptor.
Examination of clinical data for approved SPRMs like mifepristone and ulipristal acetate.

Main Results:

Mifepristone is approved for pregnancy termination.
Ulipristal acetate is approved for emergency contraception and uterine fibroid treatment.
SPRMs demonstrate inhibition of endometrial proliferation and uterine myoma growth.

Conclusions:

SPRMs show promise for treating endometriosis and other estrogen-dependent conditions.
The mechanism of inhibiting proliferation and growth is key to SPRM efficacy.
Further research into SPRMs could lead to new treatments for gynecological disorders.