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Related Experiment Video

Updated: May 11, 2026

Mouse Models for Graft Arteriosclerosis
07:37

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

Mouse models for graft arteriosclerosis.

Lingfeng Qin1, Luyang Yu, Wang Min

  • 1Department of Surgery, Yale University School of Medicine, USA.

Journal of Visualized Experiments : Jove
|May 29, 2013
PubMed
Summary
This summary is machine-generated.

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New mouse models for graft arteriosclerosis (GA) allow researchers to study smooth muscle cell proliferation in transplanted vessels. These models overcome limitations of previous methods, enabling better understanding of GA pathogenesis.

Area of Science:

  • Transplantation immunology
  • Vascular biology
  • Pathology

Background:

  • Graft arteriosclerosis (GA), or allograft vasculopathy, is a major cause of late graft loss.
  • GA is characterized by intimal smooth muscle cell proliferation and vascular stenosis.
  • Existing mouse models for GA have limitations in mimicking chronic rejection.

Purpose of the Study:

  • To develop novel mouse models for studying graft arteriosclerosis.
  • To overcome limitations of existing models for chronic rejection research.
  • To provide detailed protocols for utilizing these new GA models.

Main Methods:

  • Developed two new mouse models for GA: 1) Minor histocompatibility antigen-driven rejection in same-strain male-to-female transplants. 2) Cytokine-induced smooth muscle cell proliferation in IFN-γ receptor-deficient recipients.

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Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

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Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
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Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography

Published on: May 26, 2015

Related Experiment Videos

Last Updated: May 11, 2026

Mouse Models for Graft Arteriosclerosis
07:37

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
07:05

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
11:45

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography

Published on: May 26, 2015

  • Utilized interposition of mouse aorta segments into recipient mice.
  • Administered exogenous IFN-γ via adenoviral vector in the second model.

    • Main Results:

    • The male-to-female model allows for indolent rejection, preserving donor smooth muscle cells for weeks.
    • The IFN-γ model demonstrates donor smooth muscle cell proliferation without host rejection.
    • Both models permit genetic manipulation for studying GA progression.

    Conclusions:

    • These novel mouse models effectively recapitulate key aspects of human graft arteriosclerosis.
    • The models provide valuable tools for investigating GA pathogenesis and potential therapeutic targets.
    • Detailed protocols are provided for their implementation in research settings.