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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences01:17

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.

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Magnetic Resonance Elastography Methodology for the Evaluation of Tissue Engineered Construct Growth
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Published on: February 9, 2012

Rapid acquisition of multifrequency, multislice and multidirectional MR elastography data with a fractionally encoded

Philippe Garteiser1, Ramin S Sahebjavaher, Leon C Ter Beek

  • 1Université Paris Diderot, Sorbonne Paris Cité, Clichy, France.

NMR in Biomedicine
|May 29, 2013
PubMed
Summary

A new rapid multislice gradient-recalled echo (GRE) sequence enables fast, three-dimensional MR elastography (MRE) with improved phase-to-noise ratios. This advance significantly reduces scan times for clinical applications.

Keywords:
MR elastographyfractional encodinggradient echo

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Area of Science:

  • Medical Imaging
  • Biophysics
  • Biomedical Engineering

Background:

  • Conventional MR elastography (MRE) requires extended scan times due to limitations in motion encoding and image acquisition.
  • Current methods often rely on reduced dimensionality (1D/2D), limited slice sampling, and artifact-prone echo-planar imaging (EPI) readouts, hindering widespread clinical adoption.

Purpose of the Study:

  • To introduce a novel, rapid multislice pulse sequence for MR elastography (MRE).
  • To enable full three-dimensional (3D) motion encoding with improved efficiency and data quality.
  • To validate the sequence's capability for both monofrequency and multifrequency MRE experiments.

Main Methods:

  • Development of a rapid multislice gradient-recalled echo (GRE) MRE pulse sequence utilizing fractional encoding principles.
  • Implementation of simultaneous three-dimensional motion encoding and multi-frequency component acquisition.
  • Validation using homogeneous paraffin phantoms and in vivo liver data.

Main Results:

  • The GRE MRE sequence achieved full 3D motion encoding of isotropic voxels in large volumes in under a minute.
  • Storage modulus values in phantoms were comparable to conventional methods but with significantly reduced variance.
  • GRE MRE demonstrated superior phase-to-noise ratios (over twofold improvement) compared to conventional spin-echo EPI sequences in both phantoms and in vivo liver data.

Conclusions:

  • The developed GRE MRE sequence offers a rapid and efficient method for acquiring high-quality 3D MRE data.
  • This technique overcomes the limitations of conventional MRE, paving the way for broader clinical applications.
  • The improved signal-to-noise characteristics and reduced scan times represent a significant advancement in MRE technology.