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Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Cytotoxic Edema: Pathophysiology01:21

Cytotoxic Edema: Pathophysiology

Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
Pulmonary Edema II: Pathophysiology01:18

Pulmonary Edema II: Pathophysiology

Pulmonary edema is the accumulation of fluid in the interstitial and alveolar spaces of the lungs, impairing gas exchange and oxygen delivery. It may be cardiogenic or noncardiogenic, but both reduce oxygenation and lung compliance.Cardiogenic Pulmonary EdemaCardiogenic edema results from increased hydrostatic pressure in pulmonary capillaries, usually due to left ventricular dysfunction from myocardial infarction, heart failure, or valvular disease. Ineffective cardiac pumping causes blood to...
Fluid Connective Tissues: Blood and Lymph01:20

Fluid Connective Tissues: Blood and Lymph

Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and water.

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Related Experiment Video

Updated: May 11, 2026

A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

[Lymphedema--update].

Ram Avrahami, Menashe Haddad

    Harefuah
    |May 30, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Lymphedema, a chronic condition often secondary to cancer treatment, is increasingly managed with minimally invasive oncologic surgery and focused radiation. Standard treatment combines lymphatic massage, compression bandages, and pneumatic compression for reduced incidence and symptoms.

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    Last Updated: May 11, 2026

    A Murine Tail Lymphedema Model
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    A Murine Tail Lymphedema Model

    Published on: February 10, 2021

    A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
    09:50

    A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

    Published on: November 2, 2019

    Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
    05:44

    Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

    Published on: January 12, 2017

    Area of Science:

    • Oncology
    • Vascular Surgery
    • Medical Research

    Background:

    • Lymphedema is a chronic condition, with secondary lymphedema being the most prevalent form.
    • It often arises as a complication of cancer treatments, including surgery and radiation therapy.

    Discussion:

    • Minimally invasive oncologic surgery and focused radiation techniques are emerging to decrease lymphedema incidence and severity.
    • Aggressive management of infection and inflammation plays a crucial role in mitigating lymphedema manifestations.

    Key Insights:

    • The current gold standard for lymphedema treatment involves a multimodal approach.
    • This includes lymphatic massage, the application of elastic bandages, and sequential intermittent pneumatic compression therapy.

    Outlook:

    • Further research into novel interventional strategies is ongoing.
    • Optimizing current treatment protocols aims to improve patient outcomes and quality of life for chronic lymphedema sufferers.