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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Multifocal bilateral choroidal neovascularization in a patient on ipilimumab for metastatic melanoma

Bobeck S Modjtahedi1, Howard Maibach, Susanna Park

  • 1Department of Ophthalmology and Vision Science, University of California, Davis, Eye Center, Sacramento, CA, USA.

Cutaneous and Ocular Toxicology
|May 30, 2013
PubMed

Choroidal neovascularization membrane (CNVM) is a significant cause of ocular morbidity. Immunologic mechanisms have been proposed in the development of these lesions in exudative age related macular degeneration. Here, we describe the case of an 81-year-old man receiving ipilimumab, an immune modulating drug that enhances T cell response, for metastatic melanoma who developed three simultaneous CNVM bilaterally. This is the first case of ipilimumab-associated CNVM as well as the first case of an immune modulating drug possibly causing CNVM to our knowledge.

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