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Updated: May 11, 2026
13:56
A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
Published on: July 18, 2013
Disordered interactome of human papillomavirus
Bin Xue, Ketaki Ganti, Alejandro Rabionet
1Department of Molecular Medicine, University of South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, Florida 33612, USA. vuversky@health.usf.edu.
Current Pharmaceutical Design
|May 30, 2013
Summary
Intrinsically disordered proteins (IDPs) are crucial in biological processes and diseases like cancer. This review explores how human papillomaviruses (HPVs) exploit IDPs for their life cycle and pathogenesis.
Area of Science:
- Biochemistry
- Molecular Biology
- Virology
Background:
- Intrinsically disordered proteins (IDPs) and regions (IDPRs) lack stable structures but are vital regulators in biological processes.
- IDPs/IDPRs are implicated in disease pathogenesis, including cancer, due to their functional versatility and plasticity.
- Viruses leverage intrinsic disorder to manipulate host systems, adapt to environments, and optimize genetic material usage.
Purpose of the Study:
- To analyze the presence and characteristics of intrinsic disorder in human papillomavirus (HPV) proteins.
- To investigate how HPV proteins interact with host cellular targets through intrinsic disorder.
- To understand the role of intrinsic disorder in the life cycle and oncogenesis of HPV.
Main Methods:
- Literature review and analysis of existing studies on HPV proteins and intrinsic disorder.
- Bioinformatic analysis of HPV proteomes to identify IDPs and IDPRs.
- Examination of functional roles and interactions of disordered regions in HPV proteins.
Main Results:
- HPV proteins exhibit significant intrinsic disorder, contributing to their diverse functions.
- Disordered regions in HPV proteins are critical for host-pathogen interactions and viral replication.
- Intrinsic disorder in HPV proteins plays a role in modulating host cell pathways, facilitating viral persistence and oncogenesis.
Conclusions:
- Intrinsic disorder is a key feature of HPV proteins, enabling their complex interactions and biological activities.
- Understanding the role of intrinsic disorder in HPV is crucial for developing therapeutic strategies against HPV-associated diseases.
- HPVs effectively utilize intrinsic disorder to navigate host defenses and promote viral propagation and disease development.
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