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Updated: May 11, 2026
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
[Pulp revascularization of immature teeth with apical periodontitis: a clinical study]
Yuan Yang1, Chu-fang Peng, Man Qin
1Department of Pediatrics, Peking University School and Hospital of Stomatology, Beijing, China.
Objective:
To evaluate the clinical effect of pulp revascularization procedure for immature teeth with apical periodontitis.
Methods:
Nine immature permanent teeth diagnosed with chronic or acute apical periodontitis were recruited. According to a standard pulp revascularization procedure, the canal was disinfected with copious irrigation and a combination of three antibiotics, followed by a blood clot created in the canal. Patients were recalled periodically after the treatment. Clinical and radiographic evidence of healing was evaluated.
Results:
Eighteen to 24 months after treatment, 6 teeth showed complete resolution of the radiolucency and closure of the apex and thickening of the dentinal walls. One tooth showed healing of periodontal lesion, but the root mature was not observed. Two teeth had recurrent apical periodontitis and no evidence of healing. Apexification was performed later.
Conclusions:
Pulp revascularization could be an effective treatment for immature permanent teeth with apical periodontitis, and root elongation and narrowing canal space were observed in appropriate cases. If the treatment failed, traditional apexification could be started instead.
