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Psychophysiological responses to pain identify reproducible human clusters

Adam D Farmer1, Steven J Coen, Michiko Kano

  • 1Centre for Digestive Diseases, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK Behavioural Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan Gastrointestinal Sciences, University of Manchester, Manchester, UK Aston Brain Centre, School of Life and Health Sciences, Aston University, Birmingham, UK Department of Psychology, Institute of Psychiatry, King's College London, London, UK Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK National Heart and Lung Institute, Imperial College London, London, UK Henry Wellcome Laboratories for Integrative Neuroscience & Endocrinology, University of Bristol, Bristol, UK.

Pain
|May 30, 2013
PubMed
Summary

Researchers identified two distinct human pain clusters (PCs) based on psychophysiological and genetic profiles. These pain clusters show differences in pain perception and brain activity, potentially aiding in chronic pain risk identification.

Keywords:
Autonomic nervous systemHypothalamic-pituitary-adrenal axisPersonality traitsSerotonin transporter genotypeSomatic painVisceral pain

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