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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

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Related Experiment Video

Updated: May 11, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Testing platelet function.

Paul Harrison1, Marie Lordkipanidzé

  • 1School of Immunity and Infection, University of Birmingham Medical School, Birmingham, UK. P.Harrison.1@bham.ac.uk

Hematology/Oncology Clinics of North America
|May 30, 2013
PubMed
Summary
This summary is machine-generated.

Platelet function tests offer rapid, point-of-care assessment for bleeding disorders and can monitor antiplatelet therapy. These tests evaluate platelet function in whole blood, aiding diagnosis and management.

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Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
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Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Related Experiment Videos

Last Updated: May 11, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Area of Science:

  • Hematology
  • Clinical Pathology

Background:

  • Platelet function tests traditionally aid in diagnosing and managing bleeding disorders.
  • Platelets play a crucial role in atherothrombosis, leading to the development of new diagnostic tools.

Purpose of the Study:

  • To discuss the potential utility of available platelet function tests and instruments.
  • To highlight the advantages of point-of-care platelet function assays.

Main Methods:

  • Review of currently available dedicated platelet function instruments.
  • Discussion of point-of-care assays utilizing whole blood samples.
  • Assessment of rapid platelet function evaluation without sample processing.

Main Results:

  • Several simple-to-use platelet function instruments are available for point-of-care use.
  • These assays provide rapid assessment of platelet function in whole blood.
  • Potential utility in monitoring antiplatelet therapy and assessing thrombosis risk exists, though not currently guideline-recommended.

Conclusions:

  • Point-of-care platelet function tests offer a rapid and convenient method for assessing platelet activity.
  • These tests have potential applications in managing bleeding disorders and guiding antiplatelet therapy.
  • Further research and guideline evaluation may expand the clinical role of these assays.