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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...

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Related Experiment Video

Updated: May 11, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Platelet transfusion therapy.

Perumal Thiagarajan1, Vahid Afshar-Kharghan

  • 1Department of Pathology, Michael E. DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA. perumalt@bcm.edu

Hematology/Oncology Clinics of North America
|May 30, 2013
PubMed
Summary

Platelet transfusion therapy is crucial for cancer patients undergoing chemotherapy. This review covers current practices and guidelines for platelet transfusions in treating thrombocytopenia.

Area of Science:

  • Hematology
  • Oncology
  • Transfusion Medicine

Background:

  • Platelet transfusion is a cornerstone in managing patients with hematological and solid tumors receiving chemotherapy.
  • Significant advancements have improved platelet collection, storage, and administration over the past 60 years.
  • Thrombocytopenia management relies heavily on effective platelet transfusion strategies.

Purpose of the Study:

  • To review current practices in platelet transfusion therapy.
  • To outline the clinical approach for managing patients with thrombocytopenia.
  • To examine existing evidence-based guidelines for appropriate platelet transfusion.

Main Methods:

  • Literature review of current practices and clinical approaches.
  • Synthesis of information on platelet transfusion advancements.

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Microfluidics in Assessing Platelet Function
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Microfluidics in Assessing Platelet Function

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Last Updated: May 11, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
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Published on: January 31, 2018

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
10:32

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

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Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

  • Analysis of evidence-based guidelines for thrombocytopenia.

    • Main Results:

    • Platelet transfusion therapy is essential for cancer patients.
    • Advances have enhanced the safety and efficacy of platelet transfusions.
    • Guidelines provide a framework for appropriate transfusion use.

    Conclusions:

    • Current practices and guidelines are vital for optimizing platelet transfusion therapy.
    • Effective management of thrombocytopenia requires adherence to established protocols.
    • Continued refinement of transfusion practices improves patient outcomes in oncology.