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Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
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Impaired hypertrophy in myoblasts is improved with testosterone administration

Colleen S Deane1, David C Hughes, Nicholas Sculthorpe

  • 1Muscle Cellular and Molecular Physiology Research Group (MCMPRG), Institute of Sport and Physical Activity Research (ISPAR), University of Bedfordshire, UK; School of Health and Social Care, Bournemouth University, UK.

The Journal of Steroid Biochemistry and Molecular Biology
|May 30, 2013
PubMed
Summary

Testosterone treatment enhances muscle cell growth and differentiation, even in cells with impaired capacity. This improvement in myoblasts is mediated by the PI3K/Akt pathway.

Keywords:
AktMuscle stem cellMyostatinPI3KSatellite cellmTOR

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