Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Atrio-ventricular pressure difference associated with mitral valve motion].

L M Wang1, H Mori, K Minezaki

  • 1Department of Physiology, Tokai University, School of Medicine.

Kokyu to Junkan. Respiration & Circulation
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The effectiveness of radiotherapy for Merkel cell carcinoma].

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica·1992
Same author

Performance of an enzyme-linked immunosorbent assay system for antibodies to hepatitis C virus with two new antigens (c11/c7).

Clinical chemistry·1992
Same author

[Effect of suplatast tosilate (IPD-1151T) on types I-IV allergic reactions].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica·1992
Same author

[The first cholera case diagnosed early in the clinical laboratory by DNA probe method].

Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases·1992
Same author

Extra-adrenal pheochromocytoma-ganglioneuroma. A case report.

Pathology, research and practice·1992
Same author

[Effects of suplatast tosilate (IPD-1151T) on antibody formations in mice].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica·1992

Computer analysis of mitral valve pressure difference (PD) in dogs reveals distinct patterns during filling phases. Heart rate influences PD shape, with mitral stenosis and regurgitation altering these dynamics.

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Hemodynamics

Context:

  • Understanding mitral valve function is crucial for diagnosing and treating heart conditions.
  • Computer-aided analysis offers a precise method for evaluating hemodynamic parameters.
  • Previous studies have explored mitral valve pressure dynamics, but detailed analysis across varying heart rates and pathological conditions is ongoing.

Purpose:

  • To analyze the pressure difference (PD) across the mitral valve in dogs using a computer-aided catheter system.
  • To characterize the patterns of PD during different phases of the cardiac cycle and their correlation with heart rate (HR).
  • To investigate how artificial mitral stenosis and mitral regurgitation affect PD dynamics.

Summary:

  • Positive pressure difference (PPD) was observed during initial rapid filling.

Related Experiment Videos

  • A negative PD (NPD) followed PPD at heart rates below 100 beats/min, with a zero PD phase before the second PPD from atrial contraction.
  • At higher heart rates (>100 beats/min), PD patterns shifted to M-shaped or mono-peaked.
  • Mitral stenosis reduced the PPD peak and abolished NPD, while mitral regurgitation exaggerated PD amplitudes, indicating altered blood filling dynamics.

    • Impact:

    • This study provides detailed insights into the normal and pathological pressure dynamics of the mitral valve.
    • The findings can aid in the development of more accurate diagnostic tools for mitral valve diseases.
    • Understanding these hemodynamic changes contributes to improved therapeutic strategies for heart failure and valvular disorders.