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Related Experiment Videos

Mast cell kinetics during tumor growth.

L Lauria de Cidre1, E Sacerdote de Lustig

  • 1Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad Buenos Aires, Argentina.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|January 1, 1990
PubMed
Summary

Mast cells in mice increased significantly around tumors during growth. Tumor-secreted factors may influence mast cell behavior in surrounding tissues.

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Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Mast cells are immune cells involved in inflammation and tissue repair.
  • Tumor microenvironments can modulate immune cell behavior.
  • Understanding mast cell dynamics during tumor progression is crucial.

Purpose of the Study:

  • To investigate mast cell behavior and distribution during tumor growth in a mouse model.
  • To explore the influence of tumor-derived factors on mast cells in surrounding tissues.

Main Methods:

  • Subcutaneous implantation of Sarcoma 13 tumor and normal kidney tissue in BALBc mice.
  • Quantification of mast cell numbers and degranulation in hypodermis and peritumoral tissue over 20 days.
  • Observation of mast cell mitosis in relation to tumor proximity.

Main Results:

  • A 3-fold increase in mast cells was observed in hypodermis and peritumoral tissue by day 20.
  • Mast cell degranulation increased in peritumoral tissue with tumor growth.
  • Mast cell degranulation initially decreased in dermis/hypodermis, becoming evident on day 20.
  • Increased mast cell mitosis and degranulation were noted in tissues closer to the tumor.

Conclusions:

  • Tumor growth significantly alters mast cell populations and activity.
  • Evidence suggests tumor-secreted factors influence mast cells in both immediate and distant tumor microenvironments.
  • Further research is needed to elucidate the specific roles of mast cells in peritumoral tissues.

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