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Updated: May 11, 2026

09:23
Monitoring Neutrophil Elastase and Cathepsin G Activity in Human Sputum Samples
Published on: May 21, 2021
Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase
Nicolaos Avlonitis1, Manuelle Debunne, Tashfeen Aslam
1EaStChem, School of Chemistry, University of Edinburgh, West Mains Road, EH9 3JJ, Edinburgh, UK.
Organic & Biomolecular Chemistry
|May 30, 2013
Abstract:
Human neutrophil elastase (HNE) is a serine protease implicated in the pathogenesis of acute and chronic inflammatory disease. Here a series of, internally quenched, single fluorophore fluorescent reporters were synthesised that allowed the rapid, highly specific and sensitive analysis of HNE activity over closely related proteases.

