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A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)
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Putting a halt on PRC2 in pediatric glioblastoma
Philipp Voigt1, Danny Reinberg
1Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA.
Nature Genetics
|May 30, 2013
Abstract:
Two new studies show that the known histone H3 alteration p.Lys27Met in pediatric glioma leads to globally diminished trimethylation at histone H3 lysine 27. The mutant histone H3 acts as a selective inhibitor of the PRC2 chromatin-modifying complex by binding and presumably sequestering it, shedding light on how this variant may contribute to the etiology of these highly malignant brain tumors.
