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Clinical Significance of Antibiotic Resistance

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Related Experiment Video

Updated: May 11, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
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Published on: May 8, 2013

Methicillin-resistant coagulase-negative staphylococci (MRCoNS) by disk diffusion method.

A Rahman1, M A Hossain, S K Paul

  • 1Department of Microbiology, Northern (Pvt.) Medical College, Rangpur, Bangladesh.

Mymensingh Medical Journal : MMJ
|May 30, 2013
PubMed
Summary
This summary is machine-generated.

Coagulase-negative staphylococci (CoNS) show high resistance to common antibiotics like oxacillin. However, all CoNS isolates remained sensitive to imipenem and vancomycin, offering potential treatment options.

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Area of Science:

  • Medical Microbiology
  • Infectious Diseases

Background:

  • Coagulase-negative staphylococci (CoNS) are significant opportunistic pathogens.
  • Antimicrobial resistance in CoNS poses a growing challenge in clinical settings.

Purpose of the Study:

  • To evaluate the antimicrobial susceptibility patterns of CoNS isolates from various clinical sources.
  • To identify resistance trends and effective antibiotics against CoNS in Mymensingh Medical College Hospital, Bangladesh.

Main Methods:

  • Disk diffusion method was employed to test the susceptibility of 80 CoNS isolates.
  • Isolates were obtained from surgical wounds, pus, burn exudates, and diabetic ulcers.

Main Results:

  • High resistance rates were observed for oxacillin (45%), gentamicin (40%), cefuroxime (31%), ceftriaxone (30%), and ciprofloxacin (22%).
  • All CoNS isolates demonstrated sensitivity to imipenem and vancomycin.

Conclusions:

  • Methicillin-resistant CoNS (MRCoNS) exhibit multidrug resistance.
  • Antibiotic susceptibility testing is crucial before initiating treatment for CoNS infections to ensure effective therapy.