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Iron status in children with febrile seizure

M A Choudhury1, M Zaman, A H Mollah

  • 1Department of Paediatric Haematology & Oncology, Mymensingh Medical College (MMC), Mymensingh, Bangladesh.

Mymensingh Medical Journal : MMJ
|May 30, 2013
PubMed

Insights

Children with febrile seizures often have lower iron levels, specifically reduced hemoglobin and serum ferritin. This suggests iron status may be linked to febrile seizures in pediatric patients.

Area of Science:

  • Pediatrics
  • Clinical Chemistry
  • Hematology

Background:

  • Febrile seizures are common in children.
  • Iron deficiency is a prevalent nutritional issue in pediatric populations.
  • The relationship between iron status and febrile seizures requires further investigation.

Purpose of the Study:

  • To determine the association between iron status and febrile seizures in children.
  • To compare iron-related biomarkers in children with and without febrile seizures.

Main Methods:

  • A cross-sectional analytical study was conducted involving 120 children (6 months to 5 years).
  • Sixty children with febrile seizures (cases) and 60 age-matched children with fever but no seizures (controls) were enrolled.
  • Blood samples were analyzed for hemoglobin, MCV, MCH, serum iron, TIBC, and serum ferritin.

Main Results:

  • Children with febrile seizures had significantly lower mean hemoglobin and serum ferritin levels compared to controls.
  • High fever and continuous fever were significantly associated with febrile seizures.
  • No significant differences were observed in MCV, serum iron, or TIBC between the groups.

Conclusions:

  • Low hemoglobin and serum ferritin levels are significantly associated with febrile seizures in children.
  • Iron status, particularly iron deficiency, may play a role in the occurrence of febrile seizures.
  • Further research is warranted to explore the causal relationship and potential interventions.

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