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Correlation between microalbuminuria with complexity of coronary artery disease in diabetic patients

K N Khan1, M H Khan, M Z Haque

  • 1Department of Cardiology, United Hospital Limited, Dhaka, Bangladesh.

Mymensingh Medical Journal : MMJ
|May 30, 2013
PubMed

Insights

Microalbuminuria predicts cardiovascular disease and mortality, even without traditional risk factors. This finding is crucial for early detection in diabetes and hypertension patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Diabetology

Background:

  • Microalbuminuria is a known marker for kidney damage.
  • Its predictive role for cardiovascular diseases (CAD) and mortality, independent of other risk factors, requires further investigation.

Purpose of the Study:

  • To investigate the association between microalbuminuria and the presence and severity of coronary artery disease (CAD).
  • To determine if microalbuminuria is an independent predictor of CAD in patients undergoing coronary angiography.

Main Methods:

  • Coronary angiograms of 150 patients were analyzed for severe CAD (luminal narrowing ≥50%).
  • Urine albumin excretion was measured using immune precipitation.
  • Patients were stratified based on the presence or absence of microalbuminuria and CAD.

Main Results:

  • Coronary artery disease was present in 70.5% of patients.
  • Microalbuminuria was detected in 62.9% of patients with CAD versus 8.8% in those without (p<0.001).
  • A linear increase in CAD severity (1-2 vessel disease) was observed with increasing microalbuminuria levels.

Conclusions:

  • Microalbuminuria is a significant independent predictor of angiographically confirmed coronary artery disease.
  • The presence of microalbuminuria is linked to more severe CAD, irrespective of traditional cardiovascular risk factors.
  • These findings highlight microalbuminuria's importance in assessing cardiovascular risk, particularly in diabetic and hypertensive populations.

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