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Fluconazole for ketoconazole-resistant oropharyngeal candidiasis in HIV-1 infected patients
1Department of Infectious Diseases, University of Copenhagen, Hvidovre Hospital, Denmark.
Scandinavian Journal of Infectious Diseases
|January 1, 1990
Abstract:
The efficacy of fluconazole in doses ranging from 50 to 200 mg/day in controlling oropharyngeal candidiasis was retrospectively evaluated in 16 consecutive HIV-1-infected patients. 13 patients received fluconazole due to failure of treatment with ketoconazole, and among these 11 (84%) initially showed complete or partial remission of oropharyngeal candidiasis. 3 (27%) of these subsequently developed failure of treatment within a median observation period of 38 days. No major toxicities were observed. Fluconazole appears promising in the therapy of ketoconazole-resistant candidiasis.