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Related Concept Videos

Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Erythropoiesis01:14

Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia, and...
Erythropoiesis01:14

Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia, and...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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Author Correction: ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis.

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Related Experiment Video

Updated: May 11, 2026

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

Hematopoiesis.

Madhumita Jagannathan-Bogdan1, Leonard I Zon

  • 1HHMI/Children's Hospital Boston, Boston, MA 02115, USA.

Development (Cambridge, England)
|May 30, 2013
PubMed
Summary
This summary is machine-generated.

Hematopoiesis, the formation of blood cells, is conserved across vertebrates. Zebrafish offer a powerful model for studying this process, advancing our understanding and therapeutic development.

Keywords:
HematopoiesisMouseZebrafish

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Last Updated: May 11, 2026

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

Area of Science:

  • Comparative biology
  • Developmental biology
  • Hematology

Background:

  • Hematopoiesis, the process of blood cell formation, has been studied for over a century.
  • Vertebrate hematopoiesis exhibits conserved mechanisms with some species-specific variations.
  • Traditional model systems have provided foundational knowledge in the field.

Purpose of the Study:

  • To provide a comprehensive overview of vertebrate hematopoiesis.
  • To highlight the advantages of using zebrafish as a model organism for hematopoiesis research.
  • To underscore the impact of comparative approaches on understanding blood cell formation and disease therapies.

Main Methods:

  • Review of existing literature on vertebrate hematopoiesis.
  • Analysis of the genetic and experimental tractability of zebrafish.
  • Comparative assessment of zebrafish models with other vertebrate systems.

Main Results:

  • Demonstration of conserved fundamental principles of hematopoiesis across vertebrates.
  • Identification of zebrafish as a versatile model for large-scale genetic and chemical screens.
  • Validation of zebrafish transgenics for in-depth hematopoiesis studies.

Conclusions:

  • Zebrafish provide a powerful and accessible model for advancing hematopoiesis research.
  • Comparative studies in hematopoiesis yield crucial insights into fundamental biology and disease mechanisms.
  • Research in hematopoiesis using novel models like zebrafish contributes to the development of new therapeutic strategies.