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Updated: May 11, 2026
Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia
Published on: September 5, 2019
Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia
Fuling Zhou1, Qiang Shen, François X Claret
1Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Abstract:
It has become apparent that regulation of ROS is important in cell signaling and homeostasis. Accumulation of ROS triggers oxidative stress in various cell types and contributes to the development, progression, and persistence of cancer. Recent research has demonstrated that redox dysregulation caused by ROS promotes proliferation, differentiation, genomic, and epigenetic alterations; immune evasion; and survival in leukemic cells. ROS act as signaling molecules to regulate redox-sensitive transcriptional factors, enzymes, oncogenes, and other downstream effectors. Thus, a thorough understanding the role of ROS as key mediators in leukemogenesis is likely to provide opportunities for improved pharmacological intervention. In this review, we summarize the recent findings that support a role for ROS in the pathogenesis of AML and outline innovative approaches in the implementation of redox therapies for myeloid malignancies.
Insights
Reactive oxygen species (ROS) are crucial in cell signaling and cancer development. Understanding ROS in acute myeloid leukemia (AML) pathogenesis can lead to new redox therapies.
Area of Science:
- Biochemistry
- Cell Biology
- Oncology
Background:
- Reactive oxygen species (ROS) are vital for cell signaling and homeostasis.
- ROS accumulation induces oxidative stress, contributing to cancer development, progression, and persistence.
- Redox dysregulation by ROS impacts leukemic cell proliferation, differentiation, immune evasion, and survival.
Purpose of the Study:
- To review recent findings on the role of ROS in acute myeloid leukemia (AML) pathogenesis.
- To outline innovative redox-based therapeutic strategies for myeloid malignancies.
Main Methods:
- Literature review of recent research on ROS and leukemogenesis.
- Analysis of ROS signaling pathways in leukemia.
- Exploration of redox therapy approaches for myeloid malignancies.
Main Results:
- ROS act as signaling molecules, regulating key factors in leukemic cell survival and progression.
- Redox dysregulation is a significant factor in AML development and maintenance.
- Targeting ROS pathways presents potential for novel therapeutic interventions.
Conclusions:
- A comprehensive understanding of ROS in leukemogenesis is essential for developing targeted therapies.
- Redox therapies offer promising innovative approaches for treating myeloid malignancies.
- Further research into ROS modulation could significantly improve AML treatment outcomes.
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