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Related Concept Videos

Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Bioreactor Design and Operational System01:29

Bioreactor Design and Operational System

Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...
Applications Of NMR In Biology01:25

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
The...
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Bioreactor Controls-II01:18

Bioreactor Controls-II

In aerobic fermentations, oxygen is vital for microbial growth and metabolite production. Since air comprises only about 20% oxygen and the gas is poorly soluble in water—just 9 ppm at 20°C—supplying sufficient oxygen becomes a critical challenge, especially in high-demand processes like yeast growth or citric acid production. Even a fully saturated broth may offer only a few seconds of oxygen availability.To address this, sterile or scrubbed air is introduced into the fermentor via a sparger...

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Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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Published on: December 1, 2020

Practical use of BiNoM: a biological network manager software.

Eric Bonnet1, Laurence Calzone, Daniel Rovera

  • 1Institut Curie, Paris, France.

Methods in Molecular Biology (Clifton, N.J.)
|May 30, 2013
PubMed
Summary

The Biological Network Manager (BiNoM) is a powerful software tool for analyzing complex biological networks. This tutorial demonstrates its practical application for extracting meaningful subnetworks from large molecular maps.

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Area of Science:

  • Systems Biology
  • Bioinformatics
  • Computational Biology

Background:

  • Biological networks are crucial for understanding cellular processes.
  • Analyzing large and complex biological data presents significant challenges.
  • Existing tools may lack comprehensive features for network manipulation and analysis.

Purpose of the Study:

  • To introduce the Biological Network Manager (BiNoM) software.
  • To provide a practical guide for using BiNoM in biological network analysis.
  • To showcase BiNoM's capabilities in handling diverse biological network data.

Main Methods:

  • BiNoM software facilitates import and conversion of various systems biology file formats.
  • Utilizes a comprehensive suite of graph-based algorithms for network analysis.
  • Demonstrates practical application through a detailed case study.

Main Results:

  • BiNoM successfully handles large and complex biological datasets.
  • Enables efficient extraction of relevant subnetworks from molecular maps.
  • Proven utility in multiple projects analyzing biological networks from databases.

Conclusions:

  • BiNoM is a versatile and effective tool for biological network analysis.
  • The presented tutorial offers a practical approach to leveraging BiNoM's features.
  • BiNoM aids researchers in uncovering insights from complex biological systems.