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Updated: May 11, 2026
07:20
Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
Published on: September 10, 2014
A pilot study of muscle plasma protein changes after exercise.
Julia R Dahlqvist1, Line G Voss, Thomas Lauridsen
1Neuromuscular Research Unit 3342, Department of Neurology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Muscle & Nerve
|May 30, 2013
Summary
Troponin I (TnI) shows promise as a biomarker for severe skeletal muscle damage, appearing early in the blood. Telethonin (Tcap) was not a useful marker in this study.
Area of Science:
- Biochemistry
- Exercise Physiology
- Clinical Diagnostics
Background:
- Current biomarkers like creatine kinase (CK) and myoglobin (Mb) have limitations for assessing skeletal muscle damage.
- Investigating novel biomarkers is crucial for accurate diagnosis and monitoring.
Purpose of the Study:
- To evaluate troponin I (TnI) and telethonin (Tcap) as potential biomarkers for skeletal muscle damage.
- To compare their temporal profiles with established markers (CK, Mb) after exercise-induced muscle damage.
Main Methods:
- Plasma levels of CK, Mb, TnI, and Tcap were measured in healthy subjects and patients with muscular dystrophy or McArdle disease.
- Measurements were taken before and after exercise to assess changes over time.
Main Results:
- Myoglobin (Mb) and troponin I (TnI) were detected early in circulation.
- TnI levels increased specifically in patients with muscle disease, unlike CK which showed a delayed rise.
- Telethonin (Tcap) was undetectable in all samples.
Conclusions:
- Troponin I (TnI) may indicate severe sarcomeric damage and could complement CK and Mb in clinical practice.
- Telethonin (Tcap) is not a suitable biomarker for skeletal muscle damage based on these findings.
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