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CD30-positive peripheral T-cell lymphomas share molecular and phenotypic features.
Bettina Bisig1, Aurélien de Reyniès, Christophe Bonnet
1University Institute of Pathology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. bettina.bisig@chuv.ch
Haematologica
|May 30, 2013
Summary
CD30 expression may distinguish two distinct subtypes of peripheral T-cell lymphoma, not otherwise specified. CD30(+) tumors share molecular and protein features with anaplastic large cell lymphomas and have a better prognosis than CD30(-) types.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Background:
- Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a heterogeneous group of aggressive neoplasms.
- Previous gene expression profiling identified PTCL, NOS clusters associated with CD30 expression.
Purpose of the Study:
- To extend molecular profiling of PTCL, NOS to CD30(+) anaplastic large cell lymphomas (ALCL).
- To validate mRNA expression profiles at the protein level.
- To assess differences between CD30(+) and CD30(-) PTCL, NOS subgroups.
Main Methods:
- Reanalysis of existing transcriptomic datasets for PTCL, NOS and ALCL.
- Immunohistochemical validation of 21 markers on 80 PTCL samples (PTCL, NOS; CD30(+/-); ALCL, ALK(+/-)).
- Assessment of differences between subgroups and clinical follow-up.
Main Results:
- CD30(+) PTCL, NOS were enriched in ALK(-) ALCL-related genes compared to CD30(-) tumors.
- Immunohistochemistry revealed significant differences between CD30(+) and CD30(-) PTCL, NOS, with CD30(+) samples overlapping with ALCL.
- CD30(-) PTCL, NOS exhibited a trend towards inferior clinical outcome compared to CD30(+) subgroups.
Conclusions:
- CD30(+) PTCL, NOS share molecular and phenotypic features with ALCL.
- Significant molecular and phenotypic differences exist between CD30(-) and CD30(+) PTCL, NOS.
- CD30 expression may delineate two biologically distinct subgroups of PTCL, NOS.
