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Conducting Respiratory Oscillometry in an Outpatient Setting
Published on: April 8, 2022
Impulse oscillometry for leukotriene D4 inhalation challenge in asthma
Wei Jie Guan1, Jin Ping Zheng, Yi Gao
1State Key Laboratory of Respiratory Disease, China Clinical Research Center for Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Respiratory Care
|May 30, 2013
Summary
Impulse oscillometry (IOS) can diagnose asthma with accuracy similar to spirometry. Specific thresholds for airway impedance and resonance frequency during bronchial provocation tests indicate airway hyper-responsiveness.
Area of Science:
- Respiratory Medicine
- Pulmonary Function Testing
- Diagnostic Accuracy
Background:
- The diagnostic utility of impulse oscillometry (IOS) in bronchial provocation testing for asthma remains unclear.
- Leukotriene D(4) bronchial provocation tests are used to assess airway hyper-responsiveness.
Purpose of the Study:
- To define the positive threshold for IOS parameters in asthma diagnosis.
- To evaluate the diagnostic power of IOS compared to spirometry using leukotriene D(4) challenge.
Main Methods:
- 62 asthma patients and 21 healthy controls underwent IOS and spirometry during leukotriene D(4) challenge.
- Receiver operating characteristic curves determined the positive threshold and diagnostic parameters.
- Key IOS parameters assessed included airway impedance at 5 Hz (Z(5)) and resonance frequency.
Main Results:
- Airway impedance at 5 Hz (Z(5)), resistance at 5 Hz (R(5)), and resonance frequency showed high diagnostic power (AUCs 0.82, 0.82, 0.81).
- Positive thresholds were identified as a 57% increase in Z(5) or a 63% increase in resonance frequency.
- IOS demonstrated sensitivity and specificity comparable to spirometry for asthma diagnosis.
Conclusions:
- IOS during leukotriene D(4) challenge offers diagnostic power similar to spirometry.
- Defined increases in Z(5) or resonance frequency can serve as surrogates for FEV(1) decrease in assessing asthma hyper-responsiveness.
Keywords:
airway resistanceasthmabronchial provocation testimpulse oscillometryleukotriene D4resonance frequencyMore Related Videos
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