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Glomeruloid hemangioma in normal individuals.

Jyoti Gupta1, Rajat Kandhari, V Ramesh

  • 1Department of Dermatology and STD, National Institute of Pathology, Indian Council of Medical Research, Safdarjung Hospital, New Delhi, India.

Indian Journal of Dermatology
|May 30, 2013
PubMed
Summary
This summary is machine-generated.

Glomeruloid hemangioma, a rare vascular tumor, is typically linked to POEMS syndrome. This report details two cases presenting without POEMS, highlighting the need for high diagnostic suspicion even in solitary instances.

Keywords:
Castleman's diseasePOEMS syndromeglomeruloid hemangioma

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Glomeruloid hemangioma is a rare, benign vascular tumor.
  • It is often associated with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) and Castleman's disease.
  • Diagnosis requires a high index of suspicion due to its rarity and specific histological features.

Purpose of the Study:

  • To report two cases of glomeruloid hemangioma.
  • To emphasize that glomeruloid hemangioma can occur without POEMS syndrome.
  • To highlight the diagnostic challenges and the importance of considering it as a solitary finding.

Main Methods:

  • Case report analysis.
  • Histopathological examination of skin lesions.
  • Clinical evaluation for POEMS syndrome and Castleman's disease features.

Main Results:

  • Two patients presented with glomeruloid hemangioma.
  • Neither patient exhibited any clinical or laboratory features of POEMS syndrome.
  • The tumors were histologically confirmed as glomeruloid hemangioma.

Conclusions:

  • Glomeruloid hemangioma can manifest as a solitary cutaneous finding.
  • The absence of POEMS syndrome does not exclude the diagnosis of glomeruloid hemangioma.
  • Increased awareness and diagnostic vigilance are crucial for identifying this rare vascular tumor.