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Updated: May 11, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Insights into the Transforming Growth Factor-β Signaling Pathway in Cutaneous Melanoma

Carole Yolande Perrot1, Delphine Javelaud, Alain Mauviel

  • 1Institut Curie, Team "TGF-β and Oncogenesis", Equipe Labellisée Ligue Contre le Cancer, Orsay, France. ; INSERM U1021 Orsay, France. ; CNRS UMR 3347, Orsay, France.

Annals of Dermatology
|May 30, 2013
PubMed

Insights

Transforming growth factor-β (TGF-β) signaling acts as a tumor suppressor in normal cells but promotes melanoma progression by aiding tumor cell migration, angiogenesis, and immune evasion.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Transforming growth factor-β (TGF-β) is a key signaling molecule involved in development, homeostasis, and cancer.
  • Initially recognized for its tumor-suppressive roles, TGF-β exhibits complex, context-dependent functions in cancer progression.

Purpose of the Study:

  • To review the multifaceted roles of TGF-β signaling in melanoma.
  • To elucidate how TGF-β contributes to melanoma's pro-tumorigenic activities.

Main Methods:

  • Literature review of studies investigating TGF-β signaling pathways in melanoma.
  • Analysis of experimental and clinical data on TGF-β's impact on melanoma progression.

Main Results:

  • TGF-β signaling promotes melanoma by enhancing tumor cell migration and invasion.
  • It facilitates angiogenesis and immune evasion within the tumor microenvironment.
  • Both autocrine and paracrine TGF-β mechanisms are implicated in melanoma progression.

Conclusions:

  • TGF-β signaling is a critical driver of melanoma progression, shifting from a tumor suppressor to a promoter.
  • Targeting TGF-β pathways presents a potential therapeutic strategy for melanoma treatment.
Keywords:
MelanomaMetastasisTGF-beta signalingTherapeutic-targets

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