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Updated: May 11, 2026

A Catheter-Related Candida albicans Infection Model in Mouse

A Catheter-Related Candida albicans Infection Model in Mouse

Published on: March 22, 2024

Onychomycosis Caused by Chaetomium globosum.

Dong Min Kim¹, Myung Hoon Lee, Moo Kyu Suh

¹Department of Dermatology, College of Medicine, Dongguk University, Gyeongju, Korea.

Annals of Dermatology

|May 30, 2013

Summary

This study reports the first Korean case of onychomycosis, a nail infection, caused by the mold Chaetomium globosum. Diagnosis was confirmed through various methods, including DNA sequencing, and the patient received standard antifungal treatment.

Keywords:

Chaetomium Onychomycosis

Related Experiment Videos

Last Updated: May 11, 2026

A Catheter-Related Candida albicans Infection Model in Mouse

A Catheter-Related Candida albicans Infection Model in Mouse

Published on: March 22, 2024

Area of Science:

Mycology
Dermatology
Infectious Diseases

Background:

Onychomycosis, a common nail fungal infection, is typically caused by dermatophytes.
Nondermatophytic molds and yeasts can also cause onychomycosis, expanding the spectrum of causative agents.
The genus Chaetomium comprises dematiaceous nondermatophytic molds with saprophytic lifestyles.

Observation:

A 35-year-old male presented with brownish-yellow discoloration and subungual hyperkeratosis in multiple toenails.
Microscopic examination revealed septate hyphae, and cultures on Sabouraud's dextrose agar (SDA) without cycloheximide showed characteristic mold growth.
No growth occurred on SDA with cycloheximide, and slide cultures displayed brown septated hyphae, perithecia, and ascospores.

Findings:

This case represents the first documented instance of onychomycosis caused by Chaetomium globosum in Korea.
Morphological analysis (KOH mount, slide culture) and DNA sequencing of the internal transcribed spacer region confirmed the causative agent as C. globosum.
Genetic analysis showed a 100% match to the reference strain ATCC 6205.

Implications:

This finding broadens the etiological understanding of onychomycosis, highlighting the role of nondermatophytic molds like Chaetomium.
Accurate identification of the causative agent is crucial for effective treatment of onychomycosis.
The successful treatment with oral terbinafine and topical amorolfine suggests standard antifungal therapies are effective against C. globosum onychomycosis.