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Related Concept Videos

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Related Experiment Video

Updated: May 11, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
05:56

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Published on: August 29, 2025

Transient elastography: Kill two birds with one stone?

Grace Lai-Hung Wong1

  • 1Grace Lai-Hung Wong, Department of Medicine and Therapeutics, and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.

World Journal of Hepatology
|May 30, 2013
PubMed
Summary

Transient elastography (TE) offers a non-invasive method to assess liver fibrosis and steatosis, crucial for managing chronic liver diseases. New probes and algorithms improve accuracy, especially in obese patients and those with elevated ALT levels.

Keywords:
BiopsyCirrhosisFatty liverFibrosisHepatitisSteatosis of liver

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Magnetic Resonance Elastography Methodology for the Evaluation of Tissue Engineered Construct Growth
12:18

Magnetic Resonance Elastography Methodology for the Evaluation of Tissue Engineered Construct Growth

Published on: February 9, 2012

Area of Science:

  • Hepatology
  • Medical Imaging
  • Non-invasive Diagnostics

Background:

  • Accurate assessment of liver fibrosis and steatosis is vital for chronic liver disease management.
  • Liver biopsy is invasive and has limitations in patient acceptability.
  • Transient elastography (TE) provides a non-invasive alternative for evaluating liver fibrosis and steatosis.

Purpose of the Study:

  • To review the utility and advancements of transient elastography (TE) in assessing liver fibrosis and steatosis.
  • To highlight the impact of alanine aminotransferase (ALT) flares and obesity on TE measurements.
  • To discuss the role of the new XL probe and controlled attenuation parameter (CAP) in improving TE accuracy.

Main Methods:

  • Review of existing literature on transient elastography (TE) for liver fibrosis and steatosis assessment.
  • Analysis of factors affecting TE measurements, including ALT levels and patient obesity.
  • Evaluation of the performance of the conventional M probe and the new XL probe.
  • Assessment of the controlled attenuation parameter (CAP) for steatosis quantification.

Main Results:

  • TE is well-validated across various chronic liver diseases.
  • Elevated ALT levels require adjusted TE cutoff values to avoid misdiagnosis of fibrosis.
  • The XL probe enhances TE success rates in obese patients, with adjusted lower cutoff values.
  • Controlled Attenuation Parameter (CAP) effectively detects and quantifies liver steatosis non-invasively.
  • TE provides prognostic information, including HCC development and survival.

Conclusions:

  • Transient elastography (TE) is a reliable, non-invasive tool for assessing liver fibrosis and steatosis in chronic liver diseases.
  • Adjustments for ALT flares and the use of the XL probe improve TE accuracy in specific patient populations.
  • The integrated CAP measurement offers a comprehensive, convenient assessment of liver health.