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Whole brain radiotherapy for brain metastasis.
Emory McTyre1, Jacob Scott, Prakash Chinnaiyan
1Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Surgical Neurology International
|May 30, 2013
Summary
Whole brain radiotherapy (WBRT) is a key treatment for brain metastases, but its use is declining due to toxicity concerns. Research is ongoing to improve WBRT
Area of Science:
- Oncology
- Radiation Oncology
- Neuro-oncology
Background:
- Whole brain radiotherapy (WBRT) is a standard treatment for brain metastases and prophylaxis.
- Recent years have seen a decrease in WBRT use due to technological advances and toxicity concerns.
Purpose of the Study:
- To review the current role and future directions of WBRT in managing intracranial metastases.
- To explore strategies for improving WBRT efficacy and reducing associated toxicities.
Main Methods:
- Review of current literature and ongoing prospective studies.
- Classification of WBRT improvement strategies into reducing morbidity and enhancing efficacy.
Main Results:
- WBRT use has declined, prompting research into its optimal application.
- Two main research avenues focus on decreasing WBRT morbidity and improving its efficacy.
Conclusions:
- Ongoing research aims to enhance the efficacy/toxicity ratio of WBRT.
- Future advancements may broaden the clinical applications of WBRT for brain metastases.
