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Adjuvant! Online: mind the gap!
R Kraft Rovere1, P H Colchon, J R Rebello
1Santo Antonio Hospital, Santa Catarina, Brazil. rodrigorovere@hotmail.com
Summary
This study compared breast cancer patient outcomes in Brazil with predictions from Adjuvant! Online. The program generally matched real survival rates, except for women under 40, who had poorer disease-free survival than predicted.
Area of Science:
- Oncology
- Medical Informatics
Background:
- Accurate prognosis is crucial for tailoring breast cancer treatment.
- Adjuvant! Online is a widely used tool for predicting treatment outcomes.
Purpose of the Study:
- To evaluate the accuracy of Adjuvant! Online's prognostic predictions against actual outcomes in Brazilian breast cancer patients.
- To identify patient subgroups where predictions may differ significantly from real-world results.
Main Methods:
- Retrospective cohort study of 214 breast cancer patients in Itajaí, Brazil.
- Comparison of observed 3-year overall survival (OS) and disease-free survival (DFS) with 10-year predictions from Adjuvant! Online.
- Analysis included patient age, clinical stage, histological grade, lymph node status, subtype, and adjuvant therapy.
Main Results:
- Overall survival and disease-free survival rates showed good correspondence between observed data and Adjuvant! Online predictions.
- The shorter actual follow-up period (3 years) compared to the program's prediction (10 years) influenced the comparison.
- Patients younger than 40 years exhibited a notable decrease in disease-free survival compared to the program's prognosis.
Conclusions:
- Adjuvant! Online provides a generally reliable estimation of breast cancer prognosis for the studied population.
- Younger breast cancer patients (under 40) may require more individualized prognostic assessment as Adjuvant! Online underestimated their risk for disease recurrence.
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