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Updated: May 11, 2026
12:45
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Normalization of left ventricular ejection fraction after cardiac resynchronization therapy also normalizes survival
Mahesh Manne1, John Rickard, Niraj Varma
1Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Pacing and Clinical Electrophysiology : PACE
|May 31, 2013
Summary
Cardiac resynchronization therapy (CRT) can lead to "super-responders" with normal ejection fraction. These patients achieve survival rates comparable to the general population, suggesting reversible cardiomyopathy.
Area of Science:
- Cardiology
- Medical Devices
- Heart Failure Management
Background:
- Cardiac resynchronization therapy (CRT) improves outcomes in patients with reduced left ventricular ejection fraction (LVEF) and prolonged QRS.
- A subset of patients, termed
Purpose of the Study:
- To evaluate if
Main Methods:
- Analyzed 909 patients receiving CRT, focusing on 95
Main Results:
- Super-responders exhibited survival rates comparable to age- and sex-matched general population controls (P = 0.53).
- No significant survival difference was observed between CRT pacemaker and CRT implantable cardioverter defibrillator super-responders (P = 0.77).
- Super-responders were more frequently female (54% vs. 25%) and less likely to have coronary artery disease (42% vs. 62%).
Conclusions:
- Normalization of LVEF through CRT significantly enhances survival, bringing it in line with general population levels.
- This suggests that some CRT candidates may have a conduction abnormality-induced cardiomyopathy that is reversible with biventricular pacing.
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