Nanocarriers of solid lipid from micelles of amino acids surfactants coated with polymer nanoparticles

Polymer nanoparticle coated micelle assemblies of lauryl ester of tyrosine (LET) act as potential nanocarriers for the model solid lipid stearyl alcohol. The coating is afforded by a simple methodology of heterophase polymerization reaction of styrene or the mixture of styrene and butyl acrylate at a mole ratio of 0.8:0.2 in the presence of 200 mM LET in water. On the contrary, the polymer nanoparticles produced under similar conditions in the presence of a structurally similar surfactant, lauryl ester of phenyl alanine (LEP), failed to act as nanocarrier. The micelle templates of LET and LEP favored polymerization under controlled conditions as observed from the near monodisperse distribution of molecular weight and size of the polymers. The particle size distribution of poly(styrene) (PS) and poly(styrene-co-butyl acryalte) (PS-co-PBA) nanoparticles from LET was smaller at 24 and 20 nm in comparison to those from LEP. The encapsulation efficiency of polymer nanoparticles from LET surfactant is explained on the basis of difference in the coating of micelle assemblies, which we believe must be arising due to difference in the solubilization site of the monomers in the surfactant micelles before polymerization reaction. The solubilization of the model monomer, benzene at different regions, varying between shell and core of LET and LEP micelles is established from (1)H nuclear magnetic resonance spectra. The evidence for the coating of micelle assemblies from surface tension measurements and the encapsulation of stearyl alcohol in the polymer nanoparticle dispersions from LET drawn from transmission electron microscopy, differential scanning calorimetry, and thermogravimetric analysis is discussed.