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Updated: May 11, 2026

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
Parry-Romberg syndrome vasculopathy and its treatment with botulinum toxin
Gary E Borodic1, Paul Caruso, Martin Acquadro
1*Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Quincy; †Cambridge, Quincy, Massachusetts; ‡Department of Neuroradiology, Massachusetts General Hospital, Boston, Massachusetts; and §Department of Anesthesia, Tufts University School of Medicine, Saint Elizabeth's Hospital, Brighton, Massachusetts, U.S.A.
Abstract:
Parry-Romberg syndrome is a rare condition characterized by progressive, hemifacial atrophy, hair loss, enophthalmos, retinal vasculopathy occasionally associated with hemicranial pain syndrome (secondary trigeminal neuralgia). The cause of the condition is unknown; however, substantial evidence suggests that vasculopathy plays a significant role in the genesis of the neurologic damage and facial lipodystrophy. Herein describes a case of Parry-Romberg syndrome treated with repetitive botulinum type A toxin injections, with almost complete resolution of severe chronic pain.
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