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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Updated: May 11, 2026

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

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Multimodality therapy for advanced or metastatic sarcoma.

Kenneth Cardona1, Roger Williams, Sujana Movva

  • 1Division of Surgical Oncology, Emory Winship Cancer Institute, USA.

Current Problems in Cancer
|May 31, 2013
PubMed
Summary
This summary is machine-generated.

Chemotherapy is recommended for widespread metastatic disease, balancing patient status and drug toxicity. Limited metastatic disease may benefit from surgery or interventional radiology, with multidisciplinary input crucial for optimal patient care.

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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

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Last Updated: May 11, 2026

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Area of Science:

  • Oncology
  • Surgical Oncology
  • Interventional Radiology

Background:

  • Metastatic disease management requires tailored strategies.
  • Chemotherapy is standard for widespread metastases.
  • Surgical or interventional approaches are options for limited metastatic disease.

Purpose of the Study:

  • To outline current management strategies for metastatic disease.
  • To emphasize patient-specific treatment selection.
  • To highlight the role of multidisciplinary care.

Main Methods:

  • Review of treatment modalities for metastatic disease.
  • Consideration of patient performance status, symptoms, and toxicity.
  • Evaluation of surgical metastasectomy and interventional radiology.

Main Results:

  • Chemotherapy is the primary treatment for widespread metastatic disease.
  • Surgical or interventional radiology may offer disease control in select oligometastatic/limited metastatic cases.
  • Retrospective data show up to 50% 5-year survival in specific scenarios.

Conclusions:

  • Treatment decisions for metastatic disease should be individualized.
  • Multidisciplinary team approach is essential for optimal outcomes.
  • Specialized expertise is crucial for managing diverse soft tissue sarcoma (STS) behaviors.