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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

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Related Experiment Video

Updated: May 11, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Osteoporosis in men.

Peter R Ebeling1

  • 1Department of Endocrinology, Australian Institute of Musculoskeletal Science, North West Academic Centre, University of Melbourne, Western Health, Victoria, Australia. peterre@unimelb.edu.au

Current Opinion in Rheumatology
|May 31, 2013
PubMed
Summary
This summary is machine-generated.

Osteoporosis in men is underrecognized but treatable. Early diagnosis and treatment are crucial, as male osteoporosis increases fracture and mortality risks. Evidence-based therapies are available.

Related Experiment Videos

Last Updated: May 11, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Area of Science:

  • Gerontology
  • Endocrinology
  • Orthopedics

Background:

  • Osteoporosis in men leads to significant morbidity and mortality, with hip fractures carrying a higher mortality rate compared to women.
  • Secondary causes of osteoporosis are prevalent in men and require exclusion.
  • Accurate fracture risk assessment is essential for guiding anti-osteoporotic therapy selection.

Purpose of the Study:

  • To review the current evidence on osteoporosis diagnosis and treatment in men.
  • To highlight the importance of early recognition and intervention for male osteoporosis.
  • To discuss the role of family physicians in managing osteoporosis in men.

Main Methods:

  • Review of studies on bisphosphonate therapy, teriparatide, denosumab, and strontium ranelate in men with osteoporosis.
  • Analysis of effects on bone mineral density (BMD), bone turnover markers, and fracture reduction.
  • Evaluation of data on mortality reduction associated with osteoporosis treatment.

Main Results:

  • Bisphosphonates and teriparatide have shown reductions in vertebral fractures in men.
  • Intravenous zoledronic acid reduced fractures and mortality in elderly men and women post-hip fracture.
  • Denosumab and strontium ranelate demonstrated increases in BMD and reductions in bone turnover markers.

Conclusions:

  • Effective, evidence-based anti-osteoporosis treatments are available for men.
  • Increased awareness among family physicians and patients is needed for timely diagnosis and treatment initiation.
  • Addressing male osteoporosis is critical to reduce associated morbidity and mortality.