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Modification of amyloid-β1-42 fibril structure by methionine-35 oxidation

Liming Hou1, Hyoung-Gon Lee, Fang Han

  • 1Abbott Vascular Inc., Menlo Park, CA, USA.

Journal of Alzheimer'S Disease : JAD
|May 31, 2013
PubMed
Summary

Oxidation of methionine-35 in amyloid-beta peptides alters the structure and stability of amyloid plaques. This finding links oxidative stress and Alzheimer's disease plaque formation, impacting neurotoxicity.

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