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Identification of prostate cancer-associated microRNAs in circulation using a mouse model of disease

Luke A Selth1, Scott L Townley, Joanna L Gillis

  • 1Dame Roma Mitchell Cancer Research Laboratories, The University of Adelaide, Adelaide, SA, Australia.

Methods in Molecular Biology (Clifton, N.J.)
|May 31, 2013
PubMed

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...